Saturday, February 21, 2009

The meds have arrived!

Picture of Lupron, Menopur, Gonul F & Ovidrel
25 vials & 52 needles

Lupron Injection Box (1 box) includes
1 2.8 ml vial leuprolide injection
Menopur 75 IU Box (2 boxes) includes
5 single dose vials of Menotropins for Injection
5 single dose vials of .9% Sodium Chloride Injection
5 Qcap Vial Adapters
Gonal F Multidose 450 IU ( 5 boxes) includes
5 vials of Gonal-f multi dose (1 vial per box)
5 pre-filled syringe of bacteriostatic water for injection (1 per box)
30 administration syringes with fixed needle (27 gauge) (6 per box)
Ovidrel 250 ug/0.5mL (2 boxes) includes
2 ovidrel prefilled syringes

Wednesday, February 18, 2009

We purchased our fertility meds today!!!

Here's what $2,700 dollars will getcha in the fertility drugs arena:

Begins before and during Ovarian Stimulation (Step One below):
1. Lupron - Leuprolide Acetate is administered as a subcutaneous injection using insulin syringes. Insulin syringes are used because the measurement on the syringe is in units (i.e.: 10 units is equivalent to 0.1ml/cc). For the role it plays in assisted reproductive technologies, Leuprolide Acetate is used to reduce the amount of estrogen and testosterone in the body. This decrease in estrogen production will prevent ovulation and stop menstrual period.

Used for Ovarian Stimulation (Step One below):
2. Menopur - Menopur is a gonadotropin that contains a combination of follicle stimulating hormone (FSH) and luteinizing hormone (LH) that stimulates the ovaries to produce eggs. Menopur is administered as an injection subcutaneously.

3. GONAL-f - Gonal-f is administered as an injection subcutaneously. Gonal-f acts directly on the ovaries to help stimulate the development of follicles. Gonal-f is also used to stimulate the development of multiple eggs with assisted reproductive technologies.

Used 36 hours before Egg Retrieval (Step Two below):
4. OVIDREL - Ovidrel is administered as a subcutaneous injection. Ovidrel is used to induce ovulation (the release of an egg/eggs from the ovary) after patient monitoring indicates that sufficient follicle(s) growth has occurred.

site source: http://www.theapothecaryshop.com/FertilityMed.html

Tuesday, February 17, 2009

IVF related videos

Regina asked I post some of the great videos that I've found out on the internet. Enjoy!

IVF Overview: http://video.about.com/infertility/In-Vitro-Fertilization.htm#

Video on preparing the shots (w/o showing the administration of the shot): http://www.youtube.com/watch?v=NkzSc9hyH2Q

Egg Retrieval: http://www.youtube.com/watch?v=TC9UaNtpweE&feature=channel

Embryo Transfer (forgive the money shot at the beginning): http://www.youtube.com/watch?v=CHCE3ale7sI&feature=channel

Saturday, February 14, 2009

In Vitro Fertilization Cycle details

Tentatively, it looks like we'll be starting IVF in the next couple of weeks so I wanted to put out some information around what an IVF cycle will look like for us. Once the schedule has been finalized, I'll be sure to post it.

IVF Definition: In Vitro Fertilization literally means fertilization in glass. Instead of sperm penetrating the egg within the body (in vivo), fertilization takes place in a sterile disposable dish in a laboratory (In vitro).

Step One, Ovarian Stimulation: The treatment at this stage relies upon fertility drugs to over stimulate the development of follicles in the ovaries. The follicles are the "sacs" filled with fluid and contain the tiny, tiny egg that will later be extracted and fertilized as explained in the next step. The fertility drugs are given given by subcutaneous injection and Ed will administer the shots directly into my arm or thigh.

During this time, multiple ultrasound scans will be used to monitor the number and growth of ovarian follicles and the development of the lining of the uterus. The main focus of this stage is the over production of follicles (which contain eggs) so that when extracted in the next step, more can be fertilized and potentially used for multiple cycles assuming one cycle will not be sufficient for obtaining a pregnancy.

Step Two, Egg Retrieval: Once the eggs have matured to a certain point as determined by the various ultrasounds, the egg collection/retrieval will be scheduled. Ed will administer a shot into my tummy that will trigger the follicles and eggs to mature. Egg collection is performed vaginally using a special needle guided by ultrasound. Each follicle is aspirated until all the eggs are collected. I will push to have this procedure conducted under general anesthesia.

The follicles will immediately go to the embryologist who will analyze the quality of the eggs and we will immediately find out how many eggs were collected. The eggs and sperm will be put into a petrie dish for fertilizing the eggs. The inseminated eggs are then placed in an incubator overnight and are checked the following morning to see how many have fertilized. We will receive scheduled updates on how many embryos look viable for implantation or cryopreservation.

Step Three, Embryo Transfer: The fertilized eggs (now called embryos) are then cultured for between two and five days in the laboratory before being transferred into the uterus.

There are strict guidelines that our fertility clinic uses in the number of embryos that will be transferred (even before octomom). For my age, the protocol is to implant two or three embryos and we will pick this number with our doctor's help who will factor in the uterine reconstruction surgery, hysteroscopy and ultrasound results. The best embryos are selected for transfer either two to three days after egg collection or cultured further until day 5 (Blastocyst transfer). Any other good quality embryos may be stored by freezing (cryopreservation) for possible transfer at a later date.

Once transferred, I will remain off my feet for about 3 days and also will begin daily progesterone suppositories to aid in the embryos attaching to the uterus.

Two weeks later: I will have my hormone levels checked to see if it worked!!!

I hope this IVF introduction is helpful to understand what a cycle will look like.

Site source: http://www.content4reprint.com/science/discover-what-is-involved-in-the-ivf-process.htm

Thursday, February 12, 2009

Operative Hysteroscopy, 2/11/2009

I had the operative hysteroscopy yesterday at the fertility clinic's surgical center. It was a complete doozy. I told a good friend this morning that it was so traumatic that I'm surprised I didn't come home with a multiple personality!

I like to break down the procedure into two steps: laminaria insertion & hysteroscopy.

The laminaria was placed in my cervix on Tuesday evening, Feb. 10 to aid in cervix dilation overnight. This would make the hysteroscopy procedure go much easier.

The procedure was 20 minutes of severe cramping and twice there was pain I cannot effectively describe. The outcomes were great! There was 1 small fibroid and 1 either adhesion (scar tissue) or fatty globule that the doctor thinks he was able to remove. Better yet, I will not have to go through anything like that... we are marching to IVF!!!